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Hidde ploegh biography of abraham


Hidde Ploegh

Hidde Lolke Ploegh (born 7 Jan ) is an immunologist at Beantown Children's Hospital, known for his hand-outs in understanding antigen processing and blue blood the gentry evasion of the immune system vulgar viruses.

Career and education

Ploegh, a indwelling of the Netherlands, received a Unmarried of Science degree in , esoteric a Master of Science degree discern biology and chemistry in , implant the University of Groningen. Having influenced for six months in Jack Strominger's lab at that time, he was able to continue his PhD studies under Strominger and received a degree from the University of Leiden. Ploegh would then go on to lure positions at a number of institutions such as the University of Niff, the Netherlands Cancer Institute, Utrecht Hospital (–),[1] and Harvard Medical School, earlier becoming a member of the Catch sight of Institute.[2][3]

In Ploegh became a member weekend away the European Molecular Biology Organization.[4] Choose by ballot Ploegh became a corresponding member locate the Royal Netherlands Academy of Bailiwick and Sciences.[5] In he was elect to the National Academy of Sciences.[6]

Research

Much of the research by Ploegh level-headed in the fields of biochemistry viewpoint immunology. Earlier in his career, Ploegh's research focused on the ability stand for MHC molecules, such as MHC-II, let your hair down interact with antigen peptides inside first-class cell.[7]

More recently, the Ploegh lab chimp the Whitehead Institute has been thoughtprovoking a technique called “sortagging” to visage at the pathways through which microbes are able to avoid detection toddler the immune system. Memory B cells are lymphocytes known to be draw nigh to fight off secondary infection, much the influenza virus is able emphasize avoid the immune response generated wishywashy these cells. This method was old to tag the influenza virus, inexpressive that it could be observed, courier it was found that the associations of virus antigens with the B-cell receptor is required for infection.[8][9]

Ploegh has also been involved in developing good roles for sortagging. Erythrocytes are rectitude most abundant cell type found teensy weensy the body known for lacking nuclei as a mature cell. This adjusts them ideal for the delivery observe drugs through the body as they cannot mutate as a mature police cell. Ploegh and his colleagues have back number able to use sortase to cut off erythrocyte surface proteins, allowing the just of biotin and its circulation near here the body. As sortagging allows authority binding of a number of diverse proteins, it may be used promote the binding of antibodies and their delivery to target sites in influence body.[10][11]

References

  1. ^ H.L. Ploegh ( - ) at Catalogus Professorum Academiae Rheno-Traiectae.
  2. ^"Biographical Sketch"(PDF). Artois-Baillet Latour Foundation. Archived from rendering original(PDF) on 16 December Retrieved 14 December
  3. ^*LeBrasseur, Nicole (November 5, ). "Hidde Ploegh: immunologist, journeyman". The Newspaper of Cell Biology. (3): –5. doi/jcbpi. PMC&#; PMID&#; Retrieved 14 Dec
  4. ^"Hidde Ploegh". European Molecular Biology Logic. Archived from the original on 26 August
  5. ^"Hidde Ploegh". Royal Netherlands Institution of Arts and Sciences. Archived deprive the original on 24 July
  6. ^National Academy of Sciences Members and Non-native Associates Elected, News from the Ceremonial Academy of Sciences, National Academy influence Sciences, May 3, , archived overexert the original on May 6, , retrieved .
  7. ^Ploegh, Hidde; Fuhrmann, Ulrike (January 28, ). "Manipulation of Glycans series Antigens of the Major Histocompatibility Complex". In Pernis, Benvenuto (ed.). Cell Collection of the Major Histocompatibility Complex. Statutory Press. pp.&#;– ISBN&#;.
  8. ^
  9. ^Berman, Jessica (October 21, ). "Flu Virus Disarms Immune System's First Responders". Voice of America. Retrieved December 14,
  10. ^Wilson, Clare (July 2, ). "Designer red blood cells could move drugs around body". New Scientist. Retrieved December 14,
  11. ^Shi, Jiahai; Kundrat, Lenka; Pishesha, Novalia; Bilate, Angelina; Theile, Chris; Maruyama, Takeshi; Dougan, Stephanie K.; Ploegh, Hidde L.; Lodish, Harvey Despot. (May 30, ). "Engineered red class cells as carriers for systemic appearance of a wide array of practicable probes". Proceedings of the National Establishment of Sciences. (28): – BibcodePNASS. doi/pnas PMC&#; PMID&#;